Estronex™ Profile

The Estronex test reveals a woman's risk to breast cancer. 

Whereas mammograms are valuable for early detection of breast cancer, the Estronex test, by measuring estrogen metabolites, identifies biochemical changes in a woman's body years before a cancer cell ever forms.

Estrogen can be metabolized into various forms, including 2-hdroxyestrogens and 16-hydroxyestrogens.

The 16-hydroxyestrogens increase oxidative stress, genetic damage, oncogene expression, cellular proliferation, and inhibit apoptosis; in other words, promote cancer. 16-hydroxyestrogens are formed more under the influence of inflammation, alcohol consumption, and xenoestrogen (e.g. pesticide) exposure. 

2-hdroxyestrogens are weaker and safer metabolites. They are antioxidants and reduce estrogen receptor stimulation. 2-hdroxyestrogens also limit cell division and growth by slowing the cell cycle. 

The ratio of 2 vs. 16-hydroxyestrogens is an indicator of breast cancer risk. A urine sample can be analyzed for levels of these estrogen metabolites. Diet and lifestyle changes and nutritional supplementation can improve the 2 vs. 16-hydroxyestrogens ratio.

The Estronex test also is valuable in cases of autoimmune disease and prostate conditions.